2010 Lamar Hunt US Open Cup bracket
Click on the scores below for more information.
| FIRST ROUND | AWAY TEAM | SCORE | HOME TEAM |
| June 15 | NY Pancyprian Freedoms (USASA) | 0:2 | Long Island Rough Riders (PDL) |
| June 15 | Brooklyn Italians (USASA) | 2:4 (AET) | Harrisburg City Islanders (USL-2) |
| June 15 | Real Maryland Monarchs (USL-2) | 2:1 (AET) | Reading United (PDL) |
| June 15 | Crystal Palace Baltimore (USSF D-2) | 0:1 (AET) | Richmond Kickers (USL-2) |
| June 15 | CASL Elite (USASA) | 2:4 | Charleston Battery (USL-2) |
| June 15 | Charlotte Eagles (USL-2) | 0:1 | Carolina RailHawks (USSF D-2) |
| June 15 | Dayton Dutch Lions (PDL) | 0:2 | Rochester Rhinos (USSF D-2) |
| June 15 | Detroit United (USASA) | 0:2 | Pittsburgh Riverhounds (USL-2) |
| June 15 | KC Athletics (USASA) | 2:4 | NSC Minnesota Stars (USSF D-2) |
| June 15 | AC St. Louis (USSF D-2) | 1:0 | Des Moines Menace (PDL) |
| June 15 | Central Florida Kraze (PDL) | 1:5 (AET)` | Miami FC (USSF D-2) |
| June 15 | Tampa Bay Rowdies (USSF D-2) | 3:-0 | Legends FC (USASA) |
| June 15 | DFW Tornadoes (PDL) | 0:3 | Austin Aztex (USSF D-2) |
| June 15 | Arizona Sahuaros (USASA) | 1:1(4:2 PKs) | Ventura County Fusion (PDL) |
| June 15 | Sonoma County Sol (NPSL) | 0:3 | Portland Timbers (USSF D-2) |
| June 15 | Bay Area Ambassadors (USASA) | 2:4 | Kitsap Pumas (PDL) |
| SECOND ROUND | AWAY TEAM | SCORE | HOME TEAM |
| June 22 | Long Island Rough Riders (PDL) | 0:1 | Harrisburg City Islanders (USL-2) |
| June 22 | Real Maryland Monarchs (USL-2) | 1:3 | Richmond Kickers (USL-2) |
| June 22 | Carolina RailHawks (USSF D-2) | 1:2 | Charleston Battery (USL-2) |
| June 22 | Pittsburgh Riverhounds (USL-2) | 0:3 | Rochester Rhinos (USSF D-2) |
| June 22 | AC St. Louis (USSF D-2) | 1:0 | NSC Minnesota Stars (USSF D-2) |
| June 22 | Tampa Bay Rowdies (USSF D-2) | 1:2 (AET) | Miami FC (USSF D-2) |
| June 22 | Arizona Sahuaros (USASA) | 1:2 | Austin Aztex (USSF D-2) |
| June 22 | Portland Timbers (USSF D-2) | 4:1 | Kitsap Pumas (PDL) |
| THIRD ROUND | AWAY TEAM | SCORE | HOME TEAM |
| June 29 | New York Red Bulls (MLS) | 0:1 (AET) | Harrisburg City Islanders (USL-2) |
| June 29 | Rochester Rhinos (USSF D-2) | 1:2 | Columbus Crew (MLS) |
| June 29 | Charleston Battery (USL-2) | 0:0 (3:0 PKs) | Chicago Fire (MLS) |
| June 29 | Miami FC (USSF D-2) | 0:1 | Houston Dynamo (MLS) |
| June 29 | AC St. Louis (USSF D-2) | 0:2 | Los Angeles Galaxy (MLS) |
| June 29 | Austin Aztex (USSF D-2) | 0:1 | Chivas USA (MLS) |
| June 30 | Richmond Kickers (USL-2) | 0:2 | DC United (MLS) |
| June 30 | Seattle Sounders (MLS) | 1:1 (4:3 PKs) | Portland Timbers (USSF D-2) |
| QUARTERFINALS | AWAY TEAM | SCORE | HOME TEAM |
| July 6 | Charleston Battery (USL-2) | 0:3 | Columbus Crew (MLS) |
| July 6 | Chivas USA (MLS) | 3:1 | Houston Dynamo (MLS) |
| July 7 | LA Galaxy (MLS) | 0:2 | Seattle Sounders (MLS) |
| July 21 | Harrisburg City Islanders (USL-2) | 0:2 | DC United (MLS) |
| SEMIFINALS | AWAY TEAM | SCORE | HOME TEAM |
| September 1 | Columbus Crew (MLS) | 2:1 (AET) | DC United (MLS) |
| September 1 | Chivas USA (MLS) | 1:3 | Seattle Sounders (MLS) |
| FINAL | AWAY TEAM | SCORE | HOME TEAM |
| October 5 | Columbus Crew (MLS) | 1:2 | Seattle Sounders (MLS) |