| Qualifying Round | ||||
| Massachusetts | ||||
| 10/12/15 | Cove Albions FC | 3 : 2 | Hose IX FC | |
| 10/12/15 | New Bedford Cotton Mills | 2 : 1 | Beehive Rangers | |
| 10/23/15 | Pan Americans | 6 : 2 | Gem AA | |
| 10/23/15 | Boston Americans | w/o | Taunton City | |
| 10/23/15 | Lynn Hibernian | 1 : 0 | St. George AA | |
| 10/23/15 | Clan Macpherson | 2 : 1 | Clan Lindsay | |
| 10/23/15 | Swedish American FC | 0 : 2 | Lynn Fosse | |
| Connecticut |
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| 10/24/15 | Naugatuck FC | 4 : 1 | Bridgeport Rangers | |
| New York & New Jersey | ||||
| 10/14/15 | Cameron FC | 2 : 1 | Greenpoint FC | |
| 10/14/15 | Alley Boys FC | 2 : 0 | Clam McDuff FC | |
| 10/14/15 | Clan MacDonald FC | 3 : 1 | New York Hibernian | |
| 10/14/15 | Our Boys FC | 4 : 1 | Greenville FC | |
| 10/14/15 | Paterson Thistles | 0 : 2 | I.R.T. Strollers | |
| Rhode Island | ||||
| 10/23/15 | Plainfield FC | 0 : 6 | Smithfield Avenue Men’s Club | |
| 10/23/15 | Crompton FC | 4 : 2 | Greystone AC | |
| Eastern Pennsylvania | ||||
| 10/23/15 | Bethlehem East End | 2 : 1 | Nativity Men’s Club | |
| Northwestern New York | ||||
| 10/24/15 | Rochester City AFC | 7 : 2 | Celtic AFC | |
| Western Pennsylvania | ||||
| 10/23/15 | Treveskyn FC | 2 : 1 | Donora Steel Works | |
| 10/23/15 | Braddock FC | 3 : 0 | Pittsburgh Rovers | |
| Ohio | ||||
| 10/24/15 | Woodland Rovers | 6 : 2 | Sons of St. George | |
| Michigan | ||||
| 10/24/15 | Detroit FC | 5 : 0 | Baudette United | |
| 10/24/15 | Caledonian FC | 1 : 2 | St. George FC | |
| Illinois | ||||
| 10/24/15 | MacDuff FC | 1 : 1 (AET) | Chicago American FC | |
| 10/31/15 | R | MacDuff FC | 2 : 0 | Chicago American FC |
| 10/31/15 | Campbell Rovers | 1 : 1 (AET) | Hyde Park Blues | |
| 11/7/15 | R | Campbell Rovers | 1 : 2 | Hyde Park Blues |
| First Round | ||||
| New York & New Jersey | ||||
| 11/14/15 | Brooklyn FC | 2 : 2 | Yonkers FC | |
| 11/25/15 | R | Yonkers FC | 1 : 0 | Brooklyn FC |
| 11/14/15 | Brooklyn Celtic | 5 : 1 | Our Boys FC | |
| 11/14/15 | West Hudson AA | 1 : 1 | Clan MacDonald FC | |
| 11/21/15 | R | Clam MacDonald FC | 2:2 (AET) | West Hudson AA |
| 11/28/15 | R | West Hudson AA | 2 : 1 | Clan MacDonald FC |
| 11/14/15 | I.R.T. Strollers | 5 : 1 | Columbia Oval | |
| 11/14/15 | Alley Boys FC | 2 : 1 | Babcock & Wilcox | |
| 11/14/15 | Continental FC | 5 : 0 | Cameron FC | |
| 11/21/15 | Jersey AA | 2 : 1 | Scottish American FC | |
| Massachusetts | ||||
| 11/6/15 | New Bedford Celtic | 6 : 1 | Brockton FC | |
| 11/13/15 | New Bedford FC | 5 : 2 | Andover United | |
| 11/6/15 | Pan American FC | 8 : 2 | Charlestown FC | |
| 11/13/15 | Boston American FC | 3 : 1 | Cove Albion FC | |
| 11/13/15 | Fore River FC | 4 : 0 | Lawrence FC | |
| 11/13/15 | Fall River Rovers | 3 : 0 | Clan McPherson FC | |
| 11/13/15 | New Bedford Cotton Mills | 3 : 2 | Lynn Hibernians | |
| 11/13/15 | Farr Alpaca | 1 : 0 | Chicopee Rovers | |
| 11/13/15 | Lynn Fosse | 1 : 1 | General Electric | |
| 11/20/15 | R | Lynn Fosse | 0 : 2 | General Electric |
| Connecticut | ||||
| 11/14/15 | Bridgeport City | 5 : 0 | Naugatuck FC | |
| Rhode Island | ||||
| 11/6/15 | Howard & Bullough | 2 : 1 | Crompton FC | |
| 11/13/15 | J & P Coats | 4 : 0 | Smithfield Avenue Men’s Club | |
| Eastern Pennsylvania | ||||
| 11/13/15 | Bethlehem East Ends | 0 : 9 | Bethlehem Steel | |
| 11/13/15 | Disston AA | 3 : 0 | Wanderers FC | |
| 11/13/15 | Hibernian FC | 15 : 0 | Peabody FC | |
| 11/13/15 | Viscose FC | 2 : 1 | Putnam FC | |
| Michigan | ||||
| 11/14/15 | St. George FC | 7 : 0 | Roses FC | |
| 11/14/15 | Packard FC | 3 : 3 | Detroit FC | |
| 12/5/15 | R | Packard FC | 3 : 0 | Detroit FC |
| Northwestern New York | ||||
| 11/11/15 | Rochester City | w/o | General Electric FC | |
| Western Pennsylvania | ||||
| 11/20/15 | Treveskyn FC | 0 : 2 | Beadling FC | |
| 11/13/15 | Homestead Steel Works | 0 : 3 | Braddock FC | |
| Ohio | ||||
| 11/14/15 | Cleveland FC | 2:2 (AET) | Woodlawn Rovers | |
| 11/21/15 | R | Cleveland FC | 3 : 0 | Woodlawn Rovers |
| 11/7/15 | Thistles FC | 2 : 1 | Akron FC | |
| Illinois | ||||
| 12/5/15 | Hyde Park Blues | 2:2 (AET) |
MacDuffs | |
| 2/20/16 | R | MacDuffs | w/o | Hyde Park Blues |
| Hyde Park Blues forfeit when they did not show | ||||
| 11/14/15 | Pullman FC | 2 : 1 | Bricklayers & Masons | |
| Second Round | ||||
| New York, New Jersey & NW New York |
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| 12/12/15 | West Hudson AA | 0:0 (AET) | Yonkers FC | |
| 1/2/16 | R | West Hudson AA | 2 : 0 | Yonkers FC |
| 12/12/15 | Babcock & Wilcox | 8 : 0 | Rochester City | |
| 12/12/15 | Continental FC | 3 : 0 | I.R.T. Strollers | |
| 12/12/15 | Brooklyn Celtic | 5 : 4 | Jersey AC | |
| Massachusetts | ||||
| 12/11/15 | New Bedford FC | 1 : 0 | New Bedford Celtic | |
| 12/11/15 | Lynn Hibernian | 1 : 1 | Boston American FC | |
| 12/25/15 | R | Lynn Hibernian | 3 : 0 | Boston American FC |
| 12/25/15 | General Electric FC | 2 : 1 | Fore River FC | |
| 12/25/15 | Fall River Rovers | 1 : 0 | Pan American FC | |
| Connecticut | ||||
| 12/12/15 | Bridgeport City | 3 : 3 | Farr Alpaca | |
| 1/5/16 | R | Bridgeport City | w/o | Farr Alpaca |
| Rhode Island | ||||
| 12/11/15 | Crompton FC | 2 : 1 | J & P Coats | |
| Eastern Pennsylvania | ||||
| 12/11/15 | Bethlehem Steel | 1 : 1 (AET) | Disston AA | |
| 12/25/15 | R | Disston AA | 0 : 3 | Bethlehem Steel |
| 12/11/15 | Viscose FC | 2 : 2 | Hibernian FC | |
| 12/25/15 | R | Hibernian FC | 3 : 3 | Viscose FC |
| 1/1/16 | R | Viscose FC | 1 : 4 | Hibernian FC |
| Michigan | ||||
| 12/12/15 | Packard FC | 2 : 2 | St. George FC | |
| 12/19/15 | R | St. George FC | 0 : 0 | Packard FC |
| 1/9/16 | R | Packard FC | 2 : 1 | St. George FC |
| Ohio | ||||
| 12/12/15 | Thistles FC | 1 : 0 | Cleveland FC | |
| Illinois | ||||
| 2/27/16 | Pullman FC | 3 : 1 | MacDuff FC | |
| Western Pennsylvania | ||||
| 12/11/15 | Braddock FC | 3 : 1 | Beadlign FC | |
| Third Round | ||||
| 1/15/16 | Bethlehem Steel | 6 : 0 | Hibernian FC | |
| 1/16/16 | Continental FC | 1 : 0 | Brooklyn Celtic | |
| 1/16/16 | West Hudson FC | 2 : 1 | Babcock & Wilcox | |
| 1/15/16 | Braddock FC | 1 : 3 | Thistles FC | |
| 1/22/16 | Fall River Rovers | 4 : 0 | Lynn Hibernians | |
| 1/29/16 | General Electric FC | 2 : 7 | New Bedford FC | |
| 1/16/16 | Crompton FC | 0 : 2 | Bridgeport City | |
| 3/13/16 | Pullman FC | 2 : 0 | Hyde Park Blues | |
| Quarterfinals | ||||
| 3/5/16 | Bridgeport City AFC | 0:1 (AET) | Continental FC | |
| 3/20/16 | Thistles FC | 1 : 3 | Pullman FC | |
| 4/2/16 | West Hudson AC | 0 : 1 | Bethlehem Steel | |
| 4/1/16 | New Bedford FC | 1 : 1 | Fall River Rovers | |
| 4/8/16 | R | Fall River Rovers | 6 : 0 | New Bedford FC |
| Semifinals | ||||
| 4/15/16 | Fall River Rovers | 1 : 0 (AET) | Continental FC | |
| 4/16/16 | Pullman FC | 0:0 (AET) |
Bethlehem Steel | |
| 4/22/16 | R | Bethlehem Steel | 2 : 1 | Pullman FC |
| Final | ||||
| at Coates Field – Pawtucket, Rhode Island | ||||
| 5/16/16 | Fall River Rovers | 0 : 1 | Bethlehem Steel | |
| KEY – w/o – walkover, R – Replay | ||||