| First Round | ||||
| Eastern Bracket | ||||
| New York & New Jersey | ||||
| 11/4/17 | New York FC | 2 : 0 | Clan MacDuff | |
| 11/4/17 | Alley Boys FC | 3 : 0 | Fulton AC | |
| 11/4/17 | Clan McDonald | 1 : 0 | La Sultana FC | |
| 11/4/17 | Jersey AC | 0 : 7 | West Hudson AA | |
| 11/4/17 | Babcock & Wilcox | 1 : 1 | Scottish American FC | |
| 11/11/17 | R | Scottish American FC | 1 : 1 | Babcock & Wilcox |
| 11/18/17 | R | Scottish American FC | 2 : 1 | Babcock & Wilcox |
| 11/4/17 | Interborough Rapid Transit | w/o | White Rose FC | |
| Northern Massachusetts | ||||
| 11/4/17 | Fisk Red Tops | 1 : 2 | Fore River Rovers | |
| Connecticut | ||||
| 11/4/17 | Bridgeport City | 4 : 1 | Bridgeport Rovers | |
| Southern New England | ||||
| 11/3/17 | Greystone AC | 2 : 4 | Lonsdale FC | |
| 11/4/17 | New Bedford Celtics | 0 : 2 | Fall River Rovers | |
| 11/4/17 | Crompton FC | 2 : 3 | Pan American FC | |
| 11/4/17 | New Bedford FC | 2 : 4 | J & P Coats | |
| Western Bracket | ||||
| Eastern Pennsylvania | ||||
| 11/4/17 | Disston AA | 2 : 0 | Wanderers FC | |
| Northwestern New York | ||||
| 11/4/17 | Rochester Celtic | 4 : 0 | Kodak Park FC | |
| Western Pennsylvania | ||||
| 10/20/17 | Castle Shannon FC | 0 : 1 | McKeesport FC | |
| 11/3/17 | Beadling FC | 0 : 3 | Homestead Steel Works | |
| Ohio | ||||
| 10/28/17 | Thistle FC | w/o | Akron FC | |
| 10/28/17 | Firestone Non-Skid | 1 : 3 | Goodyear FC | |
| 11/4/17 | Cleveland FC | 2 : 0 | White Motors FC | |
| Michigan | ||||
| 11/4/17 | Rising Star FC | 0 : 2 | Corinthians FC | |
| 11/11/17 | Roses FC | 2 : 1 | Bricklayers FC | |
| Illinois | ||||
| 10/21/17 | Bricklayers FC | 1 : 2 | Harvey FC | |
| Second Round | ||||
| Eastern Bracket | ||||
| New York & New Jersey | ||||
| 12/2/17 | Scottish American FC | 1 : 1 (aet) | New York FC | |
| 3/3/18 | R | New York FC | 3 : 2 (aet) | Scottish American FC |
| 12/1/17 | Clan McDonald | 1 : 3 | Interborough Rapid Transit | |
| 12/2/17 | Paterson FC | 6 : 2 | Kinsley FC | |
| 2/17/18 | West Hudson AA | 4 : 0 | Alley Boys FC | |
| New England | ||||
| 12/3/17 | Fall River Rovers | 4 : 3 | Bridgeport City | |
| 3/2/18 | Pan American FC | 3 : 0 | J & P Coats | |
| 12/3/17 | Lynn Hibernians | 5 : 0 | Lonsdale FC | |
| 12/3/17 | Fore River FC | 3 : 2 | Lawrence Cricket & FC | |
| Western Bracket | ||||
| Illinois | ||||
| 12/2/17 | Scottish American FC | 2 : 2 | Joliet FC | |
| 12/23/17 | R | Scottish American FC | 2 : 9 | Joliet FC |
| 12/2/17 | Harvey FC | 1 : 0 | Bohemian American FC | |
| Ohio & NW New York | ||||
| 12/2/17 | Thistle FC | 0 : 3 | Rochester Celtic | |
| 12/2/17 | Goodyear FC | 1 : 2 | Cleveland FC | |
| Eastern Pennsylvania | ||||
| 12/1/17 | Disston AA | 2 : 1 | Puritan YML | |
| 12/1/17 | Bethlehem Steel | 2 : 0 | Veteran AA | |
| Western Pennsylvania | ||||
| 12/1/17 | Homestead Steel Works | 4 : 1* | McKeesport FC | |
| *McKeesport protest upheld, replay ordered | ||||
| 12/15/17 | R | McKeesport FC | 3 : 1 | Homestead Steel Works |
| Michigan | ||||
| 12/2/17 | Corinthians FC | 3 : 2 | Roses FC | |
| Third Round | ||||
| Eastern Bracket | ||||
| 1/5/18 | Disston AA | 1 : 2 (aet) | Bethlehem Steel | |
| 3/3/18 | Paterson FC | 4 : 3 | Interborough Rapid Transit FC | |
| 3/10/18 | West Hudson AA | 4 : 3 | New York FC | |
| 3/23/18 | Fall River Rovers | 3 : 1 (aet) | Pan American FC | |
| Western Bracket | ||||
| 2/16/18 | McKeesport FC | 9 : 0 | Rochester Celtic | |
| 2/23/18 | Fore River FC | 1 : 6 | Lynn Hibernians | |
| 12/30/17 | Cleveland FC | 3 : 1 | Corinthians FC | |
| 12/25/17 | Joliet FC | w/o | Harvey FC | |
| Quarterfinals | ||||
| 3/2/18 | McKeesport FC | 0 : 5 | Bethlehem Steel | |
| 3/10/18 | Joliet FC | 4 : 2 | Cleveland FC | |
| 3/17/18 | Paterson FC | 4 : 4 | West Hudson AA | |
| 3/24/18 | R | West Hudson AA | 5 : 1 | Paterson FC |
| 3/30/18 | Lynn Hibernians | 0 : 5 | Fall River Rovers | |
| Semifinals | ||||
| 3/30/18 | Bethlehem Steel | 4 : 0 | Joliet FC | |
| 4/20/18 | Fall River Rovers | 3 : 1 | West Hudson AC | |
| Final | ||||
| at Coates Field – Pawtucket, Rhode Island | ||||
| 5/5/18 | Fall River Rovers | 2 : 2 (aet) | Bethlehem Steel | |
| at Federal League Baseball Grounds – Harrison, New Jersey | ||||
| 5/19/18 | R | Bethlehem Steel | 3 : 0 | Fall River Rovers |
| KEY – w/o – walkover, R – Replay | ||||