The Wilmington Hammerheads beat an MLS team for the first time since 2003 (Dallas Burn) to advance to the Quarterfinals for the first time since that same year. They defeated the Chicago Fire by a scoreline of 1-0 at Legion Stadium in Wilmington, North Carolina. The loss marked the first time in franchise history that the Fire, a four-time US Open Cup champion, have been eliminated from the tournament by a USL Second Division team.