The professional teams in Division II and Division III leagues (USL Championship, USL League One, National Independent Soccer Association, and MLS Next Pro) now know who they will or could face in the Second Round. The United States Soccer Federation announced the pairings for the Second Round of the 107th edition of the tournament. The 31 games between April 5-7 will feature the 16 Open Division winners from the First Round along with 46 professional teams. This is the largest round in terms of number of matches in the Modern Era.
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The hosts for the Second Round, and all future rounds and the previous one, are determined by random selection. If both teams apply to host and both teams meet the federation’s minimum venue standards, then the home team is decided by random draw.
The winners from the opening round will advance to the Second Round which is scheduled to be played April 5-7. This round will introduce professional teams into the competition as all Division II (USL Championship) and Division III (MLS Next Pro, National Independent Soccer Association, and USL League One) teams will enter.
The process for determining Second Round matchups first involved pairing a First Round matchup with a nearby Division II or Division III team. After that process is done, the remaining Division II and Division III teams were paired up against each other, with teams from the same division prevented from playing each other. This was also done as travel friendly as possible with matchups that don’t fit geographically being determined by random selection.
The Oakland Roots will have the longest travel for this round. It is 2,212 miles between their respective home stadiums. Other long road trips for this round include Rio Grande Valley FC (Edinburg, TX) to North Carolina FC (Raleigh, NC) at 1,320 miles, and Central Valley Fuego FC (Fresno, CA) to El Paso Locomotive FC at 834 miles. All three are longer than the longest First Round match (Azteca FC/Denver, CO to Tulsa Athletic) at about 700 miles. These are longest road trips since the 2015 Second Round which had Portland Timbers 2 (USL) traveling to Michigan Bucks (PDL), Real Monarchs (USL) traveling to Long Island Rough Riders (PDL), and Seacoast United Phantoms (PDL) traveling Tulsa Roughnecks (USL).
Dates and times are TBD so that US Soccer can try and schedule these matches to fit within their broadcast capacity on ESPN+. There is a limited amount of matches they can broadcast at once with their broadcast partner VISTA Worldlink.
The winners from Round 2 will advance to the Third Round which is scheduled to be played April 19-21. The 17 lowest ranked Division I (Major League Soccer) teams will enter in that round.
Second Round
Division II vs. Division III (15 games)
| Date | Game (home team listed first) | Time | Venue |
| TBD | ALBION San Diego (NISA) vs. San Diego Loyal SC (USLC) | TBD | Canyon Crest Academy; San Diego, Calif. |
| TBD | Bay Cities FC (NISA) vs. Monterey Bay F.C. (USLC) | TBD | Cañada College; Redwood, Calif. |
| TBD | Charleston Battery (USLC) vs. South Georgia Tormenta FC (USLL1) | TBD | Patriot’s Point Soccer Stadium; Mt. Pleasant, S.C. |
| TBD | Chattanooga FC (NISA) vs. Memphis 901 FC (USLC) | TBD | Finley Stadium; Chattanooga, Tenn. |
| TBD | Colorado Springs Switchbacks FC (USLC) vs. Northern Colorado Hailstorm FC (USLL1) | TBD | Weidner Field; Colorado Springs, Colo. |
| TBD | Detroit City FC (USLC) vs. Michigan Stars FC (NISA) | TBD | Keyworth Stadium; Hamtramck, Mich. |
| TBD | El Paso Locomotive FC (USLC) vs. Central Valley Fuego FC (USLL1) | TBD | Southwest University Park; El Paso, Texas |
| TBD | FC Tucson (USLL1) vs. Las Vegas Lights FC (USLC) | TBD | Kino North Stadium; Tucson, Ariz. |
| TBD | Greenville Triumph SC (USLL1) vs. Oakland Roots (USLC) | TBD | Triumph Stadium at Legacy Early College; Greenville, S.C. |
| TBD | Louisville City FC (USLC) vs. Chattanooga Red Wolves SC (USLL1) | TBD | Lynn Family Stadium; Louisville, Ky. |
| TBD | North Carolina FC (USLL1) vs. Rio Grande Valley FC Toros (USLC) | TBD | WakeMed Soccer Park; Cary, N.C. |
| TBD | Orange County SC (USLC) vs. Los Angeles Force (NISA) | TBD | Orange County Great Park – Championship Soccer Stadium; Irvine, Calif. |
| TBD | Phoenix Rising FC (USLC) vs. Valley United FC (NISA) | TBD | Phoenix Rising Stadium at Wild Horse Pass; Chandler, Ariz. |
| TBD | Pittsburgh Riverhounds SC (USLC) vs. Maryland Bobcats FC (NISA) | TBD | Highmark Stadium; Pittsburgh, Pa. |
| TBD | St. Louis CITY 2 (MLSNP) vs. Indy Eleven (USLC) | TBD | Ralph Korte Stadium (Southern Illinois Univ. Edwardsville); Edwardsville, Ill. |
Division II vs. Open Division (8 games)
| Date | Game (home team listed first) | Time | Venue |
| TBD | Birmingham Legion FC (USLC) vs. Southern States SC Stars (NPSL)/Georgia Revolution FC (NPSL) winner | TBD | Protective Stadium; Birmingham, Ala. |
| TBD | FC Tulsa (USLC) vs. Tulsa Athletic (NPSL)/Azteca FC (Colo.) winner | TBD | ONEOK Field; Tulsa, Okla. |
| TBD | Hartford Athletic (USLC) vs. Hartford City FC (NPSL)/Oyster Bay United FC (N.Y.) winner | TBD | Dillon Stadium; Hartford, Conn. |
| TBD | Miami FC (USLC) vs. Miami United FC (NPSL)/City Soccer FC (Fla.) winner | TBD | Fla. International Univ. Soccer Stadium; Miami, Fla. |
| TBD | New Mexico United (USLC) vs. Las Vegas Legends FC (NPSL)/Park City Red Wolves SC (USLL2) winner | TBD | Isotopes Park; Albuquerque, N.M. |
| TBD | Sacramento Republic FC (USLC) vs. Portland Timbers U23 (USLL2)/Contra Costa FC (Calif.) winner | TBD | Heart Health Park; Sacramento, Calif. |
| TBD | San Antonio FC (USLC) vs. Denton Diablos FC (NPSL)/D’Feeters Kicks Soccer Club (Texas) winner | TBD | Toyota Field; San Antonio, Texas |
| TBD | Tampa Bay Rowdies (USLC) vs. The Villages SC (USLL2)/Orlando FC Wolves (Fla.) winner | TBD | Al Lang Stadium; St. Petersburg, Fla. |
Division III vs. Open Division (8 games)
| Date | Game (home team listed first) | Time | Venue |
| TBD | Nova FC (Va.) vs. Richmond Kickers (USLL1) | TBD | Virginia Revolution Sportsplex; Leesburg, Va. |
| -or- | |||
| Richmond Kickers (USLL1) vs. Lynchburg FC (Va.) | TBD | City Stadium; Richmond, Va. | |
| TBD | FC Motown (NPSL) vs. AC Syracuse Pulse (NISA) | TBD | Montclair State University Soccer Park; Montclair, N.J. |
| -or- | |||
| West Chester United SC (USLL2) vs. AC Syracuse Pulse (NISA) | TBD | WCUSC/PF Kildare’s Pub Turf Field; West Chester, Pa. | |
| TBD | Western Mass Pioneers (USLL2) vs. Flower City Union (NISA) | TBD | Lusitano Stadium; Ludlow, Mass. |
| -or- | |||
| Flower City Union (NISA) vs. Brockton FC United (Mass.) | TBD | Marina Auto Stadium; Rochester, N.Y. | |
| TBD | California United Strikers FC (NISA) vs. San Fernando Valley FC (Calif.)/Escondido FC (Calif.) winner | TBD | Orange County Great Park – Championship Soccer Stadium; Irvine, Calif. |
| TBD | Charlotte Independence (USLL1) vs. South Carolina United FC Bantams (USLL2)/North Carolina Fusion U23 (USLL2) winner | TBD | American Legion Memorial Stadium; Charlotte, N.C. |
| TBD | Forward Madison FC (USLL1) vs. Cleveland SC (NPSL)/Chicago FC United (USLL2) winner | TBD | Breese Stevens Field; Madison, Wis. |
| TBD | Rochester New York FC (MLSNP) vs. Ocean City Nor’easters (USLL2)/Lansdowne Yonkers FC (N.Y.) winner | TBD | Monroe Community College; Rochester, N.Y. |
| TBD | Union Omaha (USLL1) vs. Des Moines Menace (USLL2)/Minneapolis City SC (NPSL) winner | TBD | Morrison Stadium (Creighton Univ.); Omaha, Neb. |