| Round of 32 | ||||
| Eastern Bracket | ||||
| 1/3/43 | Philadelphia Americans | 1 : 0 | Baltimore Americans | |
| 1/3/43 | Brookhattan (NYC) | 7 : 2 | Fall River Rovers | |
| 1/3/43 | Kearny Scots | 3 : 1 | Pfaelzer (NYC) | |
| 1/10/43 | New York Americans | 2 : 1 | New York Germans | |
| 1/10/43 | Brooklyn Hispano | 3 : 0 | German Hungarian S.C. (NYC) | |
| 1/10/43 | Kearny Celtic | 3 : 0 | Eintracht (NYC) | |
| Philadelphia Nationals | ||||
| 1/3/43 | Brooklyn Wanderers | 1 : 0 | Swedish SC (NYC) | |
| Eastern Bracket | ||||
| 1/11/43 | Sparta SC (Chi.) | 3 : 1 | Schwaben (Chi.) | |
| 2/21/43 | Slovak SC (Chi.) | 2: 1 (aet) | Viking AA (Chi.) | |
| 4/4/43 | Falk Field Club (Mil.) | 4 : 1 | Schwaben (Mil.) | |
| 12/21/42 | Gallatin (W. Pa.) | 6 : 5 (aet) | Castle Shannon (W. Pa.) | |
| 12/21/42 | Morgan Strasser (W. Pa.) | 7 : 0 | Cuddy (W. Pa.) | |
| Croatian Eagles (Mil.) | bye | |||
| Hungarian American SC (Det.) | ||||
| ??? | ||||
| Round of 16 | ||||
| Eastern Bracket | ||||
| 1/24/43 | Kearny Celtic | 2 : 1 | Kearny Scots | |
| 1/24/43 | Philadelphia Americans | 5 : 1 | Philadelphia Nationals | |
| 2/7/43 | New York Americans | 2 : 3 | Brooklyn Wanderers | |
| 1/24/43 | Brooklyn Hispano | 4 : 3 | Brookhattan | |
| Eastern Bracket | ||||
| 3/14/43 | Sparta SC | 4 : 1 | Slovak SC | |
| 1/31/43 | Morgan Strasser | 4 : 1 | Gallatin | |
| 4/11/43 | Falk Field Club | 2 : 1 | Croatian Eagles | |
| Hungarian American SC | ||||
| Quarterfinals | ||||
| 2/21/43 | Philadelphia Americans | 1 : 0 | Brooklyn Wanderers | |
| 2/21/43 | Brooklyn Hispano | 3 : 1 | Kearny Celtic | |
| 4/25/43 | Sparta SC | 2 : 0 | Falk Field Club | |
| 3/6/43 | Hungarian American SC | 1 : 7 | Morgan Strasser | |
| Semifinals | ||||
| 3/14/43 | Brooklyn Hispano | 3 : 1 | Philadelphia Americans | |
| 5/9/43 | Sparta SC | 0 : 5(aet) | Morgan Strasser | |
| Final | ||||
| at Starlight Park – Bronx, New York | ||||
| 5/24/43 | Brooklyn Hispano | 2 : 2(aet) | Morgan Strasser | |
| REPLAY – at Starlight Park – Bronx, New York | ||||
| 5/30/43 | R | Brooklyn Hispano | 3 : 2 | Morgan Strasser |
| Brooklyn Hispano win National Challenge Cup on 5-4 aggregate | ||||
| KEY – w/o – Walkover, R – Replay, 1L – 1st Leg, 2L – 2nd Leg, 3L – 3rd Leg | ||||