2010 US Open Cup Quarterfinal Scoreboard
| July 6 Columbus Crew Stadium – Columbus, OH |
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| RECAP: Battery | Crew | Post and Courier (Charleston) | Columbus Dispatch | ||||
 Charleston Battery |
0 | FT | 3 |  Columbus Crew |
| 38′ Emilio Renteria (PK) | ||||
| 70′ Steven Lenhart (Oughton) | ||||
| 87′ Eddie Gaven (Ekpo) | ||||
| July 6 Robertson Stadium – Houston, TX |
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| RECAP: Chivas USA | Dynamo | Chronicle (Houston) | ||||
 Chivas USA |
3 | FT | 1 |  Houston Dynamo |
| Justin Braun (Trujillo) 5′ | 86′ Joseph Ngwenya | |||
| Michael Lahoud (Jazic) 65′ | ||||
| Justin Braun 90′ | ||||
| July 7 Starfire Sports Complex – Tukwila, WA |
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| RECAP: Galaxy | Sounders | Seattle Times | ||||
 Los Angeles Galaxy |
0 | FT | 2 |  Seattle Sounders |
| 50′ Nate Jaqua | ||||
| 62′ Nate Jaqua (Montano) | ||||
| July 21 Maryland Soccerplex – Boyds, MD |
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| VIDEO: D.C. United | AUDIO: Harrisburg | ||||
 Harrisburg City Islanders |
0 | FT | 2 |  D.C. United |
| SENT OFF – Tyler Ruthven 75′ | 1′ Branko Boskovic (Quaranta) | |||
| 47′ Boyzzz Khumalo | ||||