| First Round | ||||
| *advanced from qualifying rounds. All other clubs exempt from qualifying | ||||
| Eastern Bracket | ||||
| 2/14/25 | Abbot Worsted | 2 : 0 | Fore River FC | |
| 2/14/25 | Sayles Finishing Plant | 3 : 2 | Lorraine Manufacturing | |
| 2/14/25 | Bayonne FC (NJ)* | 3 : 2(aet) | Lighthouse Blue Sox* | |
| 2/22/25 | Whittall Carpet Mill | 5 : 2 | Rochester City Moose* | |
| 2/22/25 | Lexington FC (Brooklyn) | 3 : 1 | Clan Campbell FC* | |
| 2/22/25 | Ansonia FC (Conn.) | 4 : 1 | Manchester FC | |
| Shawnsheen Indians | w/o | Arlington Mills | ||
| Waypoyset FC (RI) | w/o | Boston United | ||
| Western Bracket | ||||
| 1/18/25 | Harvey FC (Ill.) | 3 : 0 | North Shore FC (Evansville) | |
| 1/18/25 | Goodyear FC (Akron) | 2 : 1 | Mahoning Valley FC (OH)* | |
| 1/18/25 | Vestaburg SC (Pit.)* | 6 : 2 | Jeanette FC (Pit.) | |
| 1/25/25 | Canadian Club (Chi.) | 3 : 0(aet) | Gillespie SC (Ill.) | |
| 1/25/25 | British War Veterans (Cle.) | 5 : 0 | Thistles FC (Cle.) | |
| 2/8/25 | Pullman FC (Chi.) | 4 : 1 | Sparta A & BA (Chi.) | |
| 2/8/25 | Olympia FC (Chi.)* | 2 : 0 | Bricklayers & Masons (Chi.) | |
| 2/8/25 | Toledo SC* | 2 : 1 | Gar Wood SC (Det.) | |
| Second Round | ||||
| Eastern Bracket | ||||
| 2/28/25 | Shawnsheen Indians | 4 : 1 | Whittall Carpet Mill | |
| 3/8/25 | Bayonne FC | 1 : 0 | Lexington FC | |
| Abbot Worsted | w/o | Waypoyset FC | ||
| 3/1/25 | Sayles Finishing Plant | 3 : 0* | Ansonia FC | |
| *Match stopped in 51st minutre due to heavy rain | ||||
| 3/14/25 | Sayles Finishing Plant | 9 : 2 | Ansonia FC | |
| Western Bracket | ||||
| 2/15/25 | Harvey FC | 2 : 0 | Olympia FC | |
| 2/15/25 | Canadian Club | 2 : 1 | Pullman FC | |
| 2/15/25 | Thistles FC | 2 : 0 | Goodyear FC | |
| 2/15/25 | Vestaburg FC | 2 : 1 | Toledo SC | |
| Quarterfinals | ||||
| 3/1/25 | Canadian Club | 1 : 1 | Harvey FC | |
| 3/8/25 | R | Canadian Club | 1 : 1 | Harvey FC |
| 3/15/25 | R | Canadian Club | 1 : 0 | Harvey FC |
| 3/1/25 | Thistles FC | 3 : 2 | Vestaburg SC | |
| 3/21/25 | Shawsheen Indians | 2 : 0 | Bayonne FC | |
| 3/21/25 | Abbot Worsted | 3 : 2 | Sayles Finishing Plant | |
| Semifinals | ||||
| 3/22/25 | Canadian Club | 2 : 1 | Thistles FC | |
| 4/4/25 | Shawsheen Indians | 2 : 1 | Abbot Worsted | |
| Final | ||||
| at Mark’s Stadium, Tiverton, Rhode Island | ||||
| 4/19/25 | Shawsheen Indians | 3 : 0 | Canadian Club | |
| KEY – w/o – Walkover, R – Replay | ||||
| NOTE – Teams from St. Louis and the American Soccer League did not participate due to a disagreement with the USFA’s percentage of gate receipts for cup games, as well as their teams playing preliminary games against amateur clubs that often drew smaller crowds. | ||||